Adding Insulin to Metformin for Diabetes Associated With Increased Risk of Death

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June 10, 2014

CHICAGO — June 10, 2014 — Among patients with diabetes who were receiving metformin, the addition of insulin compared with a sulfonylurea was associated with an increased risk of non-fatal cardiovascular outcomes and all-cause death, according to a study published in the June 11 issue of JAMA.

The American Diabetes Association and the European Association for the Study of Diabetes recommend that, for patients with preserved kidney function, diabetes treatment begin with metformin and lifestyle changes to ...

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